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目的:观察经皮冠状动脉介入(PCI)治疗所致外周血妊娠相关血浆蛋白A(cPAPP-A)水平的变化。方法:应用ELISA法检测20例冠心病(CAD,CAD组)患者PCI术前及术后20h、30h的cPAPP-A水平,另23例冠状动脉造影(CAG)正常的人群(对照组)为对照。结果:CAD组术后20hcPAPP-A水平(6.61±2.56)μg/L,与术前[(3.82±1.41)μg/L、对照组(3.72±1.52)μg/L]比较,均差异有统计学意义;术后30h(4.92±1.35)μg/L,显著下降,但仍显著高于术前。结论:PCI引发斑块破裂可导cPAPP-A水平升高。
Objective: To observe the change of pregnancy related plasma protein A (cPAPP-A) in peripheral blood induced by percutaneous coronary intervention (PCI). Methods: The levels of cPAPP-A in 20 patients with coronary artery disease (CAD and CAD) before PCI and at 20 and 30 h after PCI were detected by ELISA. The other 23 patients with normal coronary angiography (CAG) . Results: Compared with preoperative [(3.82 ± 1.41) μg / L and 3.72 ± 1.52 μg / L], the level of cPAPP-A at 20h after operation in CAD group was 6.61 ± 2.56 μg / L, Significance; After 30h (4.92 ± 1.35) μg / L, significantly decreased, but still significantly higher than preoperative. Conclusions: PCI-induced plaque rupture leads to elevated cPAPP-A levels.