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阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的病因是复杂的和多因素的。大量研究表明,软腭的形态和组织病理学的很多改变都与OSAHS密切相关,软腭后移造成腭帆间隙消失,呼吸道扩张肌的肌纤维分布异常导致的肌肉活动减弱,软腭中脂肪分布增加,肌肉呈现的炎症改变及腭咽部神经纤维的损伤等一系列解剖形态及显微结构上的诸多改变,构成了OSAHS发病机制中的重要环节。但软腭与OSHAS发病更为确切的因果联系,有待于作大规模的临床调查,在分子水平更进一步地研究。
The causes of obstructive sleep apnea-hypopnea syndrome (OSAHS) are complex and multifactorial. Numerous studies have shown that many changes in the morphology and histopathology of the soft palate are closely related to OSAHS. The soft palate posterior displacement results in the disappearance of the palatal clearance, the decreased muscle activity due to abnormal muscle fiber distribution in the dilated muscle, the increased fat distribution in the soft palate, Inflammation and velopharyngeal nerve fiber damage and a series of anatomical changes and many other microstructural changes constitute the pathogenesis of OSAHS an important part. However, the soft palate and the onset of OSHAS a more exact causal link to be large-scale clinical investigations to be conducted further study at the molecular level.