转铁蛋白是一种细胞生长因子,在体内担当运铁功能。上海肿瘤研究所免疫室已研制了一批分泌抗人体转铁蛋白单克隆抗体的杂交瘤株。经蛋白电泳吸印实验(Western Blot)证实为转铁蛋白单抗。目前瘤株已稳定分泌单抗9个月,单抗为鼠IgG_1型。杂交瘤细胞染色体数平均为93在免疫病理研究中初步表明用该单抗可显示出某些肿瘤细胞上转铁蛋白的受体。由于转铁蛋白及其受体与癌基因或其产物有关,在体外试验表明免疫系统中NK细胞作用也受其影响,某些肝 Transferrin is a cell growth factor that acts as a transporter of iron in the body. The Department of Immunization of Shanghai Cancer Research Institute has developed a series of hybridoma strains that secrete anti-human transferrin monoclonal antibodies. Western blot confirmed the transferrin monoclonal antibody. At present, the tumor strain has been stable and secreted monoclonal antibody for 9 months. The monoclonal antibody is mouse IgG1 type. The average chromosome number of the hybridoma cells was 93. In the immunopathological study, it was initially shown that the use of this monoclonal antibody can display transferrin receptors on certain tumor cells. Since transferrin and its receptors are related to oncogenes or their products, in vitro experiments have shown that the role of NK cells in the immune system is also affected by them, and some livers