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目的 :探讨大鼠腰神经根受压后背根神经节和脊髓后角含生长抑素 m RNA阳性神经元的变化。方法 :选用12只 Wistar大鼠 ,随机分为实验组和正常组 ,实验组用硅胶管压迫右 L4脊神经后根 ,采用原位杂交法结合图像分析进行研究。结果 :大鼠腰神经根受压 4周后 ,实验组背根神经节和脊髓后角内生长抑素 m RNA阳性神经元神经元的数量和平均面积明显增多 ,与正常组相比均有显著性差异。神经元以中、小型神经元为主。结论 :大鼠腰神经根受压后可使背根神经节和脊髓后角内神经元生长抑素 m RNA的表达上调 ,提示生长抑素可能与根性腰腿痛的发生有关
Objective: To investigate the changes of somatostatin m RNA positive neurons in dorsal root ganglion and spinal dorsal horn after lumbar nerve root compression in rats. Methods: Twelve Wistar rats were randomly divided into experimental group and normal group. In the experimental group, the posterior roots of right L4 spinal nerve were compressed by silicone tube. The in situ hybridization and image analysis were used to study. RESULTS: After 4 weeks of lumbar nerve root compression in rats, the number and average area of somatostatin m RNA positive neurons in dorsal root ganglion and spinal dorsal horn in experimental group were significantly increased compared with those in normal group Sex differences. Neurons in small and medium-sized neurons. Conclusion: The lumbar nerve root compression may up-regulate the expression of somatostatin m RNA in dorsal root ganglion and spinal dorsal horn neurons, suggesting that somatostatin may be related to the occurrence of lumbosacral pain