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目的探讨人工流产术后残留保守治疗效果的影响因素。方法选取2011年1月至2014年4月武汉市蔡甸区人民医院收治的人工流产术后发生残留的248例患者的临床资料,根据不同治疗方案分为A组(59例)、B组(63例)、C组(62例)和D组(64例),A、B、C组采用的米非司酮用药方案分别为200 mg×7 d、100 mg×14 d、50 mg×28 d,D组给予常规治疗,统计阴道出血情况、血清β-人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)值等指标,比较各组治疗效果。依据各组的治疗结果分为治愈组和保守治疗失败组,分析治疗效果的影响因素。结果 A、B、C、D组治愈率分别为67.8%(40/59)、54.0%(34/63)、46.8%(29/63)、10.9%(7/64),4组之间比较差异有统计学意义(P<0.05)。血清β-HCG值、残留物大小、残留物血流阻力指数在治愈组和保守治疗失败组之间差异有统计学意义(P<0.05),进行多因素Logistic回归显示上述指标均为影响疗效的独立因素。结论血清β-HCG值、残留物大小、残留物血流阻力指数和米非司酮使用剂量与人工流产术后残留保守治疗效果相关。
Objective To investigate the influencing factors of residual conservative treatment after induced abortion. Methods The clinical data of 248 patients with residual after abortion from January 2011 to April 2014 in Caidian District People’s Hospital of Wuhan were divided into group A (59 cases), group B (63 cases) (N = 62) and group D (n = 64). The regimens of mifepristone used in groups A, B and C were 200 mg × 7 d, 100 mg × 14 d, 50 mg × 28 d The patients in group D were given routine treatment, statistics of vaginal bleeding, serum chorionic gonadotropin (HCG) and other indicators, and compared the curative effect of each group. According to the treatment results of each group is divided into the cure group and the conservative treatment failure group, analyze the influencing factors of the treatment effect. Results The cure rates of group A, B, C and D were 67.8% (40/59), 54.0% (34/63), 46.8% (29/63) and 10.9% (7/64), respectively The difference was statistically significant (P <0.05). Serum β-HCG value, residue size, residue flow resistance index in the cured group and conservative treatment failed to statistically significant difference (P <0.05), multivariate Logistic regression showed that the above indicators are affecting the efficacy Independent factors. Conclusions Serum β-HCG value, residue size, residue flow resistance index and mifepristone dosage are related to residual conservative treatment after induced abortion.