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目的探讨盆腔内异症与非内异症患者血清及腹腔液中CA125相关性。方法将56例腹腔镜检查患者分为盆腔内异症38例(病例组)及非盆腔内异症18例(对照组),应用磁性分离酶联免疫法测定两组血清及腹腔液中CA125水平。结果内异症组血清及腹腔液中CA125水平显著高于对照组(血清39.72±40.15U/ml对比10.25±7.23 U/ml,P=0.000;腹腔液1494.08±1256.55 U/ml对比815.40±652.85U/ml,P=0.002),且两者呈线性正相关(r=0.592);内异症组分期越晚的患者血清及腹腔液中CA125值均显著升高(P=0.000)。结论盆腔内异症与非内异症组患者血清及腹腔液中CA125水平呈正相关,且腹腔液中CA125水平显著增高。内异症的发展可能与血清及腹腔液中CA125水平的显著升高有关。
Objective To investigate the correlation between CA125 in serum and peritoneal fluid in patients with pelvic endometriosis and non-endometriosis. Methods Fifty-six patients undergoing laparoscopy were divided into 38 cases of pelvic endometriosis (case group) and 18 cases of non-pelvic endometriosis (control group). Serum and peritoneal fluid CA125 levels were measured by magnetic separation enzyme-linked immunosorbent assay . Results Serum and peritoneal CA125 levels in patients with endometriosis were significantly higher than those in the control group (serum 39.72 ± 40.15U / ml vs 10.25 ± 7.23U / ml, P = 0.000; peritoneal fluid 1494.08 ± 1256.55U / ml vs. 815.40 ± 652.85U / ml, P = 0.002), and there was a linear positive correlation between them (r = 0.592). Serum and peritoneal CA125 levels were significantly increased in patients with later stages of endometriosis (P = 0.000). Conclusions Pelvic endometriosis is positively correlated with CA125 level in serum and peritoneal fluid in patients with non-endometriosis, and the level of CA125 in peritoneal fluid is significantly higher. The development of endometriosis may be related to the significant increase of CA125 level in serum and peritoneal fluid.