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瘤内肿瘤相关巨噬细胞(TAMs)在结直肠癌(CRC)中的作用尚不明确。Kang JC、Chen JS、Lee CH等人通过研究TAMs与CRC临床病理特征的关系,以及基质金属蛋白酶(MMP)-2和MMP-9的表达情况,以探索TAMs在结直肠癌中的作用。为检测瘤内巨噬细胞的生物学效应,研究中将肿瘤细胞与巨噬细胞联合培养,并观察癌细胞的功能变化。研究发现,MMP-2
The role of intratumoral tumor-associated macrophages (TAMs) in colorectal cancer (CRC) is unclear. Kang JC, Chen JS and Lee CH et al investigated the role of TAMs in colorectal cancer by studying the relationship between TAMs and clinicopathological characteristics of CRC and the expression of matrix metalloproteinase (MMP) -2 and MMP-9. To detect the biological effects of intratumoral macrophages, tumor cells and macrophages were co-cultured in the study and the function of cancer cells was observed. Study found that, MMP-2