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目的探讨马来酸依那普利叶酸片治疗老年高血压病的疗效及安全性。方法选择75例老年原发性高血压患者随机分配到3个治疗组中,分别接受依那普利10.0 mg、马来酸依那普利叶酸片10.0mg/0.4mg和马来酸依那普利叶酸片10.0mg/0.8mg,每日1次,连续治疗8周。结果两种配比马来酸依那普利叶酸片组降压效果、降低同型半胱氨酸疗效均优于依那普利组(P<0.01)。用药前后血常规、尿常规、电解质、血脂、血糖、肝肾功能均无明显改变(P>0.05)。结论马来酸依那普利叶酸片用于老年高血压患者降压、降低同型半胱氨酸安全、有效。
Objective To investigate the efficacy and safety of enalapril maleate folic acid tablets in the treatment of elderly patients with essential hypertension. Methods Seventy-five elderly patients with essential hypertension were randomly assigned to three treatment groups receiving either enalapril 10.0 mg, enalapril maleate folic acid tablets 10.0 mg / 0.4 mg, and enalapril maleate Folic acid tablets 10.0mg / 0.8mg, day 1, continuous treatment for 8 weeks. Results Compared with enalapril group, the two antihypertensive effects of folic acid and enalapril maleate were better than that of enalapril group (P <0.01). Before and after treatment of blood, urine, electrolytes, blood lipids, blood glucose, liver and kidney function were no significant changes (P> 0.05). CONCLUSION: Enalapril maleate folate tablets are effective in lowering blood pressure and lowering homocysteine in elderly hypertensive patients.