本文研究了荧光法测定头孢氨苄的血药浓度及其药物动力学。实验结果表明,血清浓度在1～20μg/ml范围内,荧光强度与浓度有较好的线形关系,r=0.9975。回收率为94.7%±2.3%(n=5),CV=2.39%。浓度时间曲线(头孢氨苄0.5g,PO)显示为一室模型。平均药物动力学参数(n=8):Ka=1.7500(h~(-1)),K=0.7365(h~(-1)),T_(1/2)=0.9401(h),T_(max)=1.18(h),C_p=19.64(μg/ml),V_a/F=13568.2(ml)。 In this paper, the determination of cefalexin plasma concentration and its pharmacokinetics by fluorescence method. The experimental results show that there is a good linear relationship between the fluorescence intensity and the concentration of serum concentration in the range of 1 ~ 20μg / ml, r = 0.9975. The recovery was 94.7% ± 2.3% (n = 5), CV = 2.39%. The concentration time curve (cefalexin 0.5g, PO) showed a one-compartment model. The average pharmacokinetic parameters (n = 8) were as follows: Ka = 1.7500 (h -1), K = 0.7365 h -1, T 1/2 = 0.9401 h, ) = 1.18 (h), C_p = 19.64 (μg / ml), V_a / F = 13568.2 (ml).