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目的 探讨 PS2 蛋白在溃疡性结肠炎组织中异位表达的意义。方法 用免疫组织化学法检测了30例溃疡性结肠炎和 2 8名正常人结肠组织中 PS2 和 CEA的表达。结果 显示 30例溃疡性结肠炎 PS2 蛋白阳性的 7例 ,阳性率 2 3.3% ,PS2 只在伴有不典型增生的溃疡性结肠炎中表达 ;而 CEA阳性的 2 2例 ,阳性率 73.3%。2 8名正常人结肠组织中 PS2 阳性的 1例 ,CEA阳性的 2例。结论 PS2 蛋白在溃疡性结肠炎组织中的异位表达可作为溃疡性结肠炎的病情观察指标
Objective To investigate the significance of PS2 protein ectopic expression in ulcerative colitis. Methods The expressions of PS2 and CEA in 30 cases of ulcerative colitis and 28 normal human colon tissues were detected by immunohistochemistry. The results showed that 30 cases of ulcerative colitis PS2 protein positive in 7 cases, the positive rate of 3.3%, PS2 only with atypical hyperplasia of ulcerative colitis expression; and CEA positive in 22 cases, the positive rate of 73.3%. There were 1 PS2 positive and 2 CEA positive in 28 normal human colon tissues. Conclusion Ectopic expression of PS2 protein in ulcerative colitis can be used as an indicator of ulcerative colitis