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目的观察子宫颈癌患者动脉灌注化疗的护理干预效果。方法选择2014年1月—2016年1月收治的子宫颈癌患者60例,随机分为干预组与对照组,每组30例。两组均给予动脉灌注化疗,观察组在此基础上给予护理干预。观察两组治疗疗效;干预前后采用焦虑自评量表(self-rating anxiety scale,SAS)对焦虑状态进行评分,采用抑郁自评量表(self-rating depression scale,SDS)对抑郁状态进行评分;统计两组治疗过程中的不良反应。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果两组治疗后经B超检查显示病灶体积缩小;阴道流血、流液、下腹痛症状于介入后3~5 d缓解。两组均有2例Ⅲb期患者经2次动脉化疗栓塞无效改为放疗,其余均顺利手术切除。两组疗效比较差异无统计学意义(P>0.05)。与干预前比较,干预后对照组SAS、SDS评分比较差异无统计学意义(均P>0.05),干预组SAS、SDS评分比较差异有统计学意义(均P<0.05);干预后干预组SAS、SDS评分[(37.15±6.78)、(41.09±6.43)分]与对照组[(47.08±6.65)、(53.18±5.22)分]比较差异有统计学意义(均P<0.05)。对照组不良反应发生率为33.33%,干预组为6.67%,两组不良反应发生率比较差异有统计学意义(P<0.05)。结论子宫颈癌患者动脉灌注化疗过程中实施护理干预,可改善患者焦虑抑郁状态,降低不良反应发生率。
Objective To observe the nursing effect of arterial infusion chemotherapy in patients with cervical cancer. Methods Sixty patients with cervical cancer who were admitted from January 2014 to January 2016 were randomly divided into intervention group and control group, with 30 cases in each group. Both groups were given arterial infusion chemotherapy, the observation group on the basis of nursing intervention. The anxiety state was assessed by self-rating anxiety scale (SAS) before and after intervention, and the depression status was scored by self-rating depression scale (SDS) Statistics two groups of adverse reactions in the course of treatment. Measurement data were compared using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results After treatment, B-ultrasound showed that the lesion volume was reduced. The symptoms of vaginal bleeding, fluid and lower abdominal pain were relieved 3 ~ 5 days after intervention. In both groups, 2 patients with stage Ⅲb disease were treated with radiotherapy instead of 2 with arterial chemoembolization, and the rest were successfully surgically removed. There was no significant difference between the two groups (P> 0.05). Compared with pre-intervention, SAS and SDS scores of the control group had no significant difference after intervention (all P> 0.05), SAS and SDS scores of the intervention group had significant difference (all P <0.05); intervention group SAS , The SDS score [(37.15 ± 6.78), (41.09 ± 6.43) points] was significantly different from the control group [(47.08 ± 6.65), (53.18 ± 5.22) points] (all P <0.05). The incidence of adverse reactions in the control group was 33.33% and in the intervention group was 6.67%. There was significant difference in the incidence of adverse reactions between the two groups (P <0.05). Conclusion Nursing intervention in patients with cervical cancer during arterial infusion chemotherapy can improve patients’ anxiety and depression status and reduce the incidence of adverse reactions.