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目的探讨三磷酸腺苷(ATP)结合盒子转运子1(ATP-binding cassette transporter1,ABCA1)基因多态性与腔隙性脑梗死(lacunar infarction)的相关性。方法采用病例-对照方法对109例腔隙性脑梗死患者和339例健康对照者进行研究,并用多聚合酶链式反应(PCR)和限制性片段长度多态性测定ABCA1R219K多态性。结果对照组ABCA1R219K基因型的频率为RR32.4%、RK49.6%和KK18.0%;腔隙性脑梗死组基因型的频率为RR27.5%、RK55.1%和KK17.4%。ABCA1R219K基因型和等位基因频率分布在腔隙性脑梗死组与对照组之间差异无显著性(P>0.05)。结论未发现ABCA1R219K基因多态性与腔隙性脑梗死存在相关关系。
Objective To investigate the association of ATP-binding cassette transporter1 (ABCA1) gene polymorphism with lacunar infarction in patients with lacunar infarction. Methods A total of 109 patients with lacunar infarction and 339 healthy controls were studied by case-control method. The ABCA1R219K polymorphism was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism. Results The frequency of ABCA1R219K genotype in control group was RR32.4%, RK49.6% and KK18.0%. The frequency of genotypes in lacunar infarction group was RR27.5%, RK55.1% and KK17.4%. ABCA1R219K genotype and allele frequency distribution in the lacunar infarction group and the control group no significant difference (P> 0.05). Conclusion There is no correlation between ABCA1R219K gene polymorphism and lacunar infarction.