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目的通过观测甲巯咪唑在治疗甲亢患者过程中β2-球蛋白含量与甲状腺激素含量的变化情况,研究两者的相关性及甲巯咪唑的药理学作用机制。方法随机选取73例甲状腺功能亢进症患者作为患者组,并且随机调取在本院进行身体健康检查的70名健康人体检资料作为对照组,给予73例患者甲巯咪唑作为甲亢治疗方案药物,在治疗过程中监测甲状腺激素水平变化情况以及使用放射免疫法(RIA)检测各组β2-球蛋白水平,并进行数据资料分析。结果在应用甲巯咪唑治疗甲亢的过程中,T4和T3水平升高组患者血清中β2-球蛋白水平(2764.15±179.67)明显高于对照组(1838.82±155.29)。在治疗过程中甲巯咪唑对甲状腺激素水平变化无明显影响,对β2-球蛋白含量存在一定影响,差异无统计学意义(P>0.05)。结论甲状腺功能亢进症患者血清中β2-球蛋白含量与甲状腺激素水平存在密切关系,β2-球蛋白含量可以作为甲巯咪唑的药理学作用及甲亢患者的临床疗效检测指标。
Objective To observe the changes of β2-globulin and thyroid hormones in patients with hyperthyroidism during the treatment of patients with hyperthyroidism and to explore the correlation between the two and the pharmacological mechanism of methimazole. Methods A total of 73 patients with hyperthyroidism were selected as the patient group, and 70 healthy people in our hospital were randomly assigned to take the physical examination as the control group. 73 patients were given methimazole as the treatment program of hyperthyroidism. Thyroid hormone levels were monitored during treatment and radioimmunoassay (RIA) was used to detect β2-globulin levels in each group, and data analysis was performed. Results In the application of methimazole treatment of hyperthyroidism, serum levels of β2-globulin in patients with elevated T4 and T3 levels (2764.15 ± 179.67) were significantly higher than those in the control group (1838.82 ± 155.29). During the course of treatment, methimazole had no significant effect on the level of thyroid hormone, but had some influence on the content of β2-globulin, with no significant difference (P> 0.05). Conclusions Serum levels of β2-globulin in patients with hyperthyroidism are closely related to the level of thyroid hormone. The content of β2-globulin can be used as the pharmacological effect of methimazole and the clinical efficacy of hyperthyroidism.