论文部分内容阅读
在正常组织同种移植的免疫增强研究中,必须解答的主要问题之一,就是增强抗体对MHC的几个区都具有特异性,还是仅对一个区具有特异性。在皮肤和肾同种移植的早期研究中观察到,免疫增强活性主要来自抗Ia抗体。然而,在最近的研究中发现,不仅抗Ia抗体具有免疫增强活性,而且抗MHC其他产物的抗体-抗K、D抗体,同样具有免疫增强活性。作者认为,结果不一致的原因可能与移植组织的类型有关。因此本文着重有小鼠皮肤和心脏移植的实验资料,
One of the main questions that must be answered in an immune enhancement study of normal tissue allografts is to increase the specificity of the antibody for several regions of the MHC or for only one region. It has been observed in early studies of skin and kidney allograft that the immune enhancing activity is mainly from anti-Ia antibodies. However, it has been found in recent studies that not only the anti-Ia antibody has immunopotentiating activity, but also the anti-K and D antibodies against the other MHC class antibodies, which also have immunopotentiating activity. The author believes that the reason for the inconsistency may be related to the type of transplant organization. Therefore, this article focuses on mouse skin and heart transplantation experimental data,