论文部分内容阅读
目的探讨CT联合血清肿瘤标记物在卵巢交界性肿瘤(BOT)和卵巢良性上皮性肿瘤(BET)中的鉴别诊断价值。方法回顾性分析经手术和病理证实的28例BOT和41例BET患者的CT资料,收集术前血清糖类抗原-125(CA125)、人附睾分泌蛋白4(HE4)、癌胚抗原(CEA)的检测结果,比较两组肿瘤的CT影像特点和血清肿瘤标记物的水平。结果两种肿瘤实性成分、厚分隔、壁结节的出现率差异有统计学意义(χ~2=25.135、5.240、5.066,P<0.05);血清CA125水平的差异有统计学意义(Z=3.202,P<0.05),但血清HE4、CEA水平的差异无统计学意义(Z=0.330、1.122,P>0.05);血清CA125水平鉴别两种肿瘤的最佳临界值、敏感性、特异性分别为42.45U/mL、53.6%、85.4%;实性成分、厚分隔诊断两种肿瘤的总确诊率为78.5%;实性成分、厚分隔、血清CA125水平诊断两种肿瘤的总确诊率为81.2%。结论卵巢上皮性肿瘤出现实性成分、厚分隔及血清CA125水平升高有助于鉴别BOT和BET。
Objective To investigate the differential diagnostic value of CT combined with serum tumor markers in borderline ovarian tumors (BOT) and benign ovarian tumors (BET). Methods CT data of 28 patients with BOT and 41 patients with BET confirmed by operation and pathology were retrospectively analyzed. Preoperative serum carbohydrate antigen -125 (CA125), human epididymis secretory protein 4 (HE4), carcinoembryonic antigen (CEA) Of the test results, CT images of the two groups of tumor characteristics and serum tumor markers compared. Results There were significant differences in the occurrence of solid component, thick separation and wall nodules (χ ~ 2 = 25.135,5.240,5.066, P <0.05), and the difference of serum CA125 level was statistically significant (Z = 3.202, P <0.05). However, there was no significant difference in serum HE4 and CEA levels (Z = 0.330,1.122, P> 0.05). The serum CA125 level was used to identify the optimal threshold, sensitivity and specificity 42.45U / mL, 53.6% and 85.4% respectively. The total diagnosis rate of solid tumor and solid tumor was 78.5%. The total diagnosis rate of the two tumors with solid component, thick separation and serum CA125 level was 81.2 %. Conclusion The ovarian epithelial tumor with solid components, thick separation and serum CA125 levels help to identify BOT and BET.