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1956年Sutherland发现肾上腺素能激活细胞膜上一种有赖于Mg~(++)的腺苷环化酶促使三磷酸腺苷(ATP)生成环磷酸腺苷(cAMP),1963年Ashman等发现环磷酸鸟苷(cGMP)随乙酰胆碱α～阻滞剂而增加。随后许多研究资料证明cAMP和cGMP作为蛋白质肽类激素的第二倍使不但调节机体正常代谢,而且cAMP与cGMP的水平和许多疾病密切相关。近年cAMP与cGMP对心血管系统的功能与高血压病的发病机理也有许多
In 1956, Sutherland found that an adenosine cyclase relying on Mg ~ (++) activated adenosine triphosphate (ATP) to form cyclic adenosine monophosphate (cAMP) on the adrenergic activated cell membrane. In 1963, Ashman et al found that cyclic guanosine monophosphate cGMP) increases with acetylcholine alpha-blockers. Subsequent data from many studies demonstrate that cAMP and cGMP, as the second most common protein peptide hormones, not only regulate the body’s normal metabolism, but also cAMP and cGMP levels are closely related to many diseases. In recent years cAMP and cGMP on the cardiovascular system function and the pathogenesis of hypertension there are many