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目的联合检测血中游离前列腺特异抗原(fPSA)、总前列腺特异抗原(tPSA)和(f/t)PSA比值以期提高前列腺癌诊断的特异性和准确性。方法73例前列腺疾病患者分成两组,前列腺癌组和前列腺增生组,应用全自动电化学发光免疫分析仪(Elecsys2010)检测tPSA、fPSA和(f/t)PSA比值。并进行统计学分析。结果两组间tPSA与fPSA测定值差异无统计学意义(P>0.05),两组间(f/t)PSA差异有统计学意义(P<0.01)。以tPSA正常值4.0为临界点,tPSA诊断前列腺癌的敏感性为86.7%,特异性为37.9%。以(f/t)PSA正常参考值0.25为临界点,(f/t)PSA诊断前列腺癌的敏感性为80.0%,特异性为82.8%。结论联合检测tPSA、fPSA和(f/t)PSA比值可提高前列腺癌诊断的特异性和准确性。
Objective To evaluate the specificity and accuracy of fPSA, tPSA and (f / t) PSA in the diagnosis of prostate cancer. Methods Totally 73 patients with prostatic diseases were divided into two groups: prostate cancer group and benign prostatic hyperplasia group. The ratios of tPSA, fPSA and (f / t) PSA were measured by using an automated chemiluminescence immunoassay analyzer (Elecsys 2010). And statistical analysis. Results There was no significant difference between the two groups in the determination of tPSA and fPSA (P> 0.05). The difference of f / t PSA between the two groups was statistically significant (P <0.01). TPSA normal value of 4.0 as the critical point, tPSA diagnosis of prostate cancer was 86.7%, specificity was 37.9%. To (f / t) PSA normal reference value of 0.25 as the critical point, (f / t) PSA diagnosis of prostate cancer was 80.0% sensitivity and specificity of 82.8%. Conclusion The combined detection of tPSA, fPSA and (f / t) PSA ratio can improve the specificity and accuracy of diagnosis of prostate cancer.