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Objectives:To investigate the effects of insulin resistance on serum androgen leveland ovulation of women with polycystic ovary syndrome (PCOS) and observe clinic roleof acarbose in the treatment of hyperinsulinemia,postprandial hyperglycemia andanovulation.Methods:14 women accompanied by postprandial hyperglycemia with PCOS wereadministrated by acarbose for 12 weeks.14 age-matched individuals who had similarbody mass index and normal menstruation were served as controls.Results:Serum T levels declined significantly from 4.09±1.04 nmol/L to 1.71±0.54 nmol/L(P<0.001),after acarbose treatment for 12 weeks.12 out of 14 cases re-stored ovulation and menstrual cycles after acarbose treatment,among which 4 gotpregnant.Conclusion.Acarbose may play a role on reducing postprandial hyperglycemia andHbAic levels,increase ISI and FSG/FI,indirectly reduce serum androgen levels throughreducing plasma insulin level and recover ovarian ovulation in PCOS women with postprandial hyperglycemia.
Objectives: To investigate the effects of insulin resistance on serum androgen leveland ovulation of women with polycystic ovary syndrome (PCOS) and observe clinic role of acarbose in the treatment of hyperinsulinemia, postprandial hyperglycemia and anovulation. Methods: 14 women accompanied by postprandial hyperglycemia with PCOS wereadministrated by Results: Serum T levels were significantly decreased from 4.09 ± 1.04 nmol / L to 1.71 ± 0.54 nmol / L (P <0.001), respectively after acarbose treatment for 12 weeks.12 out of 14 cases re-stored ovulation and menstrual cycles after acarbose treatment, among which 4 gotpregnant.Conclusion. Acarbose may play a role on reducing postprandial hyperglycemia andHbAic levels, increase ISI and FSG / FI, reduce serum androgen levels throughreducing plasma insulin level and recover ovarian ovulation in PCOS women with postprandial hyperglycemia.