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目的探讨全血黏度与脑小血管病(SVD)相关性。方法选取正常对照组35例和脑小血管病组35例,根据头颅MRI表现将SVD组分为脑白质病变(WML)组和腔隙性脑梗死(LI)组,比较SVD组、WML组、LI组与正常对照组的全血黏度及其他脑血管危险因素,并对全血黏度进行多因素Logistic回归分析。结果全血黏度的增高与SVD及WML的发生相关(OR=1.518;1.503),当调整其他危险因素后,P<0.05;全血黏度的增高与LI的发生相关(OR=1.272),然而调整其他脑血管危险因素后,P>0.05。结论全血黏度的增高可能是脑小血管病特别是WML的独立危险因素,其与脑小血管病特别是脑白质病变密切相关。
Objective To investigate the relationship between whole blood viscosity and cerebrovascular disease (SVD). Methods 35 cases of normal control group and 35 cases of cerebral vascular disease group were selected. The SVD group was divided into WML group and lacunar infarction group according to the cranial MRI findings. The SVD group, WML group, LI group and normal control group of whole blood viscosity and other cerebrovascular risk factors, and whole blood viscosity by multivariate logistic regression analysis. Results The increase of whole blood viscosity correlated with the occurrence of SVD and WML (OR = 1.518; 1.503), P <0.05 after adjustment for other risk factors. The increase of whole blood viscosity was correlated with the occurrence of LI (OR = 1.272) After other cerebrovascular risk factors, P> 0.05. Conclusion The increase of whole blood viscosity may be an independent risk factor for cerebrovascular disease, especially WML, which is closely related to cerebrovascular disease, especially leukoaraiosis.