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目的比较I型上皮性卵巢癌(epithelial ovarian cancer,EOC)与Ⅱ型上皮性卵巢癌临床特征。方法回顾性分析2012年1月-2015年7月吉林大学白求恩第一医院妇科初治的83例Ⅰ型EOC与143例Ⅱ型EOC,分析两组患者的临床病理资料。结果 I型EOC患者平均年龄[(50±14)岁]明显小于Ⅱ型组[(54±9)岁],差异有统计学意义(P<0.05);其绝经比例(45.85%)小于Ⅱ型卵巢癌组(60.80%),差异有统计学意义(P<0.05);Ⅱ型EOC患者腹水检出率较高(72.00%),术前血清CA125及HE4水平较I型高(均P<0.05);I型EOC满意切除手术率及完全分期手术率较Ⅱ型组高,而对TC化疗方案敏感度较差。两组患者之间的腹水或腹腔冲洗液脱落细胞检出率、临床分期、FIGO分期差异均有统计学意义(均P<0.05)。结论Ⅱ型卵巢癌在临床病理特征方面有别于I型患者,二元论可指导卵巢癌的诊断及个体化治疗。
Objective To compare the clinical features of epithelial ovarian cancer (IOC) with type Ⅱ epithelial ovarian cancer (OCC). Methods A retrospective analysis of 83 cases of type Ⅰ EOC and 143 cases of type Ⅱ EOC from January 2012 to July 2015 in Bethune First Hospital of Jilin University was performed. The clinicopathological data of the two groups were analyzed. Results The mean age of patients with type I EOC [(50 ± 14) years] was significantly lower than that of patients with type Ⅱ [(54 ± 9) years] (P <0.05) (P0.005). The positive rate of ascites in type Ⅱ EOC patients was higher (72.00%), the level of serum CA125 and HE4 in patients with ovarian cancer was significantly higher than that in type Ⅰ patients (all P <0.05) ); Type I EOC satisfactory resection rate and complete staging were higher than those in type II group, but less sensitive to TC chemotherapy regimen. The detection rates of ascites or peritoneal lavage fluid exfoliated cells between the two groups were significantly different (all P <0.05). Conclusions Type II ovarian cancer is different from type I patients in clinical and pathological features. Dualism can guide the diagnosis and individualized treatment of ovarian cancer.