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目的观察庆大霉素对前庭及耳蜗的损害。方法对肌肉注射庆大霉素（250mg·kg－1／d）连续3天和7天的两组豚鼠进行前庭和耳蜗功能与形态的观察。结果发现用药3天仅影响前庭，而用药7天则前庭和耳蜗均受损害，提示庆大霉素早期损害前庭的特点可以报警耳蜗的损害。结论因此，在应用庆大霉素过程中，发现前庭功能改变时，如能及时停药，可以避免耳聋的发生。
Objective To observe the damage of vestibular and cochlear to gentamicin. Methods The vestibular and cochlear function and morphology were observed in two groups of guinea pigs injected intraperitoneally with gentamicin (250 mg · kg-1 / d) for 3 days and 7 days. The results found that medication only affects the vestibular three days, and medication 7 days the vestibular and cochlear impaired, suggesting that early damage to gentamicin vestibular characteristics can alert the damage of the cochlea. Conclusion Therefore, in the application of gentamicin, found that changes in vestibular function, if promptly discontinued, can prevent the occurrence of deafness.