中老年男性迟发性性腺功能减退症(late-onsethypogonadism,LOH)的发病机制是多种机制损害雄激素的正常分泌和生物活性,包括雄激素水平下降和雄激素受体异常,是原发性和继发性因素共同作用的结果。综述LOH的发病机制、发病率及危险因素,后者包括疾病和药物的影响、过度肥胖、不良生活方式、环境与遗传因素的影响、精神心理因素、社会经济因素和文化教育水平。 The pathogenesis of late-onsexypogonadism (LOH) in middle-aged and elderly men is that multiple mechanisms impair the normal secretion and biological activity of androgens, including decreased androgen levels and androgen receptor abnormalities, which are primary and The result of secondary factors together. The pathogenesis, incidence and risk factors of LOH are reviewed. The latter include the effects of diseases and drugs, obesity, unhealthy lifestyles, environmental and genetic factors, psychosocial factors, socio-economic factors and education levels.