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目的观察疏风解毒胶囊联合抗生素治疗老年急性细菌性上呼吸道感染的临床疗效。方法选择2013—2014年上海市杨浦区中心医院急诊科诊治的老年急性细菌性上呼吸道感染患者231例,随机分为联合治疗组112例与对照组119例。在对症治疗基础上,对照组患者给予抗生素治疗,联合治疗组患者给予抗生素联合疏风解毒胶囊治疗,均治疗7 d。比较两组患者治疗第1、3天体温、白细胞计数、炎性细胞因子〔白介素1(IL-1)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)〕、降钙素原(PCT)及第3天体温恢复正常率。结果治疗第1天两组患者体温、白细胞计数及血清IL-1、IL-6、TNF-α、PCT水平比较,差异无统计学意义(P>0.05);治疗第3天联合治疗组患者体温、白细胞计数及血清IL-1、IL-6、TNF-α、PCT水平低于对照组(P<0.05)。治疗第3天联合治疗组患者体温恢复正常率为88.4%,高于对照组的66.4%(P<0.05)。结论疏风解毒胶囊联合抗生素治疗老年急性细菌性上呼吸道感染疗效确切,能有效控制患者体温及炎症。临床试验注册号Chi CTR-TRC-14004695。
Objective To observe the clinical effect of Shufeng Jiedu capsule combined with antibiotics in the treatment of acute bacterial upper respiratory tract infection in the elderly. Methods A total of 231 elderly patients with acute bacterial upper respiratory tract infection who were diagnosed and treated in emergency department of Yangpu District Central Hospital from 2013 to 2014 were randomly divided into combined treatment group (112 cases) and control group (119 cases). On the basis of symptomatic treatment, the patients in the control group were treated with antibiotics. The patients in the combined treatment group were given antibiotics combined with Shufeng Jiedu Capsule for 7 days. The body temperature, white blood cell count, inflammatory cytokines (IL-1, IL-6, TNF-α), calcitonin The original (PCT) and body temperature returned to normal on the third day. Results There was no significant difference in body temperature, white blood cell count and serum IL-1, IL-6, TNF-α and PCT levels between the two groups on the first day of treatment (P> 0.05) , White blood cell count and serum IL-1, IL-6, TNF-α, PCT levels were lower than the control group (P <0.05). The normalized rate of body temperature recovery in the combination therapy group on day 3 was 88.4%, which was higher than that in the control group (66.4%, P <0.05). Conclusion Shufeng Jiedu capsule combined with antibiotics in the treatment of acute bacterial upper respiratory tract infection in elderly patients with effective treatment can effectively control the body temperature and inflammation. Clinical trial registration number Chi CTR-TRC-14004695.