论文部分内容阅读
目的探讨转移因子联合双歧杆菌口服治疗对鹅口疮患儿临床症状及免疫功能的影响。方法选择2014年1月—2015年6收治的鹅口疮患儿84例为研究对象,根据入院先后顺序分为观察组和对照组各42例;对照组采用常规2%碳酸氢钠清洁口腔(2次/d)+制霉菌素(10 U/kg·d,3次/d)+维生素B2研粉口服等综合治疗;观察组在对照组基础上联合应用转移因子(≤1岁每次5 ml,>1岁每次10 ml,2次/d)+双歧杆菌口服治疗(0.5~1.0 g/次,2~3次/d);两组均以7 d为1个疗程,连续治疗2个疗程;比较两组患者临床症状改善情况、免疫功能和治疗效果。计量资料采用t检验,计数资料采用χ~2检验,P<0.05为差异有统计学意义。结果观察组有效率(90.48%)明显高于对照组(69.05%),对比差异有统计学意义(P<0.05)。观察组复发率(7.14%)明显低于对照组(23.81%),对比差异有统计学意义(P<0.05)。治疗2周后,观察组患儿口腔白膜、烦躁不安、拒食及口腔唾液镜检真菌菌丝或孢子积分[(1.28±0.34)、(1.41±0.52)、(1.33±0.46)、(1.15±0.27)分]均明显低于对照组[(1.57±0.48)、(1.77±0.60),(1.82±0.51)、(1.48±0.39)分],对比差异均有统计学意义(均P<0.05)。治疗2周后,观察组T淋巴细胞CD3~+、CD4~+、CD4/CD8均明显高于对照组,观察组T淋巴细胞CD8+明显低于对照组[(65.48±6.54)%、(46.32±5.12)%、(1.77±0.34)、(26.15±2.65)%、(57.21±5.64)%、(38.25±4.36)%、(1.34±0.32)、(28.65±2.45)%],对比差异均有统计学意义(均P<0.05)。观察组血清免疫球蛋IgA、IgG、IgM含量均明显高于对照组[(2.45±0.35)、(16.45±1.68)、(2.16±0.42)、(2.27±0.34)、(14.36±1.42)、(1.78±0.40)g/L],对比差异均有统计学意义(均P<0.05)。结论转移因子联合双歧杆菌治疗有助于迅速缓解鹅口疮患儿临床症状,改善免疫功能,降低复发率,提高治疗效果。
Objective To investigate the effects of transfer factor combined with oral bifidobacterium on the clinical symptoms and immune function in thrush children. Methods Eighty-four cases of thrush patients admitted from January 2014 to June 2015 were selected and divided into observation group (42 cases) and control group (42 cases). The control group was treated with conventional 2% sodium bicarbonate solution (2 (N = 10), nystatin (10 U / kg · d, 3 times / d) + oral administration of vitamin B2 and other comprehensive treatment; observation group on the basis of the control group combined with transfer factor ,> 1 year old each 10 ml, 2 times / d) + Bifidobacterium oral treatment (0.5 ~ 1.0 g / time, 2 to 3 times / d); both groups were 7 d for a course of treatment, continuous treatment 2 A course of treatment; clinical symptoms of two groups were compared to improve the immune function and treatment. Measurement data using t test, count data using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results The effective rate (90.48%) in the observation group was significantly higher than that in the control group (69.05%), the difference was statistically significant (P <0.05). The recurrence rate of observation group (7.14%) was significantly lower than that of control group (23.81%), the difference was statistically significant (P <0.05). After treatment for 2 weeks, the mycorrhizal or spore integrals of oral albuginea, irritability, antifeedant and oral salivary fungi in the observation group [(1.28 ± 0.34), (1.41 ± 0.52), (1.33 ± 0.46), (1.15 ± 0.27) were significantly lower than those in the control group [(1.57 ± 0.48), (1.77 ± 0.60), (1.82 ± 0.51), (1.48 ± 0.39) points respectively. The differences were statistically significant (all P <0.05) . After treatment for 2 weeks, CD3 +, CD4 +, CD4 / CD8 of T lymphocytes in the observation group were significantly higher than those in the control group. The CD8 + of T lymphocytes in the observation group was significantly lower than that in the control group [(65.48 ± 6.54)%, (46.32 ± 5.12%, (1.77 ± 0.34), (26.15 ± 2.65)%, (57.21 ± 5.64)%, (38.25 ± 4.36)%, (1.34 ± 0.32), (28.65 ± 2.45)%, respectively Significance (both P <0.05). The contents of IgA, IgG and IgM in serum immunoglobulin in the observation group were significantly higher than those in the control group [(2.45 ± 0.35), (16.45 ± 1.68), (2.16 ± 0.42), (2.27 ± 0.34) and (14.36 ± 1.42) 1.78 ± 0.40) g / L], the differences were statistically significant (all P <0.05). Conclusion The combination of transfer factor and Bifidobacterium treatment can help to quickly relieve the clinical symptoms of thrush children, improve immune function, reduce the recurrence rate and improve the therapeutic effect.