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益生菌是一类能在肠道内定植,维护肠道菌群平衡,并刺激肠黏膜免疫组织,对肠黏膜免疫有重要影响的有益微生物群落。新生儿由于其自身发育的原因,具有免疫功能低下、肠道功能不健全、肠道细菌种类及数量较少等特点。现从益生菌对新生儿肠道免疫调节作用,益生菌与新生儿坏死性小肠结肠炎、早产儿喂养不耐受、新生儿腹泻病、新生儿黄疸、变态反应性疾病,益生菌的安全性等方面综述益生菌在新生儿的临床应用和研究进展,旨在使广大儿科医师更好地了解和应用益生菌制剂,使此类药物更合理地应用于临床。
Probiotics are a group of beneficial microorganisms that can colonize the intestine, maintain the balance of gut flora and stimulate the intestinal mucosal immune tissues, which have an important impact on intestinal mucosal immunity. Neonates due to their own development, with immune dysfunction, intestinal dysfunction, intestinal bacteria and the number of fewer types of characteristics. Probiotics from the intestinal immune regulation of newborns, probiotics and neonatal necrotizing enterocolitis, premature infant feeding intolerance, neonatal diarrhea, neonatal jaundice, allergic diseases, the safety of probiotics And other aspects of probiotics probiotics in neonatal clinical application and research progress, designed to enable the majority of pediatricians to better understand and apply probiotic preparations, so that more reasonable use of such drugs in clinical.