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目的:探讨益气养阴中药联合GP方案治疗晚期非小细胞肺癌(NSCLC)的近期疗效、生活质量改善和毒副反应。方法:采用随机单盲法,将60例晚期NSCLC患者随机分为2组各30例。对照组予GP方案治疗;治疗组在对照组治疗的基础上予益气养阴中药治疗。观察2组近期疗效、中医证候改善、生活质量评分及毒副反应发生率。结果:2组近期疗效有效率比较,差异无显著性意义(P>0.05);治疗组中医证候改善优于对照组,差异有显著性意义(P<0.05);治疗组KPS评分治疗前后差值明显优于对照组,差异有非常显著性意义(P<0.01);治疗组毒副反应发生率较对照组显著降低,差异有显著性意义(P<0.05)。结论:益气养阴中药联合GP方案化疗,可显著改善晚期NSCLC患者中医证候,提高生活质量,降低毒副反应发生率。
Objective: To explore the short-term curative effect, quality of life improvement and side effects of Qi-supplementing and Nourishing Yin combined with GP regimen in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: Sixty patients with advanced non-small cell lung cancer (NSCLC) were randomly divided into two groups of 30 patients. The control group was treated with GP regimen; the treatment group was given Yiqi Yangyin Chinese herbal medicine on the basis of the control group. Two groups were observed the short-term curative effect, TCM syndrome, quality of life score and the incidence of toxic and side effects. Results: There was no significant difference between the two groups in the short-term effective rate (P> 0.05). The improvement of TCM syndrome in the treatment group was better than that in the control group (P <0.05). The KPS score in the treatment group was significantly lower (P <0.01). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group, with significant difference (P <0.05). Conclusion: Yiqi Yangyin combined with GP regimen chemotherapy can significantly improve the TCM syndromes of patients with advanced NSCLC, improve the quality of life and reduce the incidence of toxic reactions.