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1 临床资料 我院自1989～1997年共收集肝硬变食道静脉曲张破裂出血在1000ml以上45例,其中男38例,女7例,年龄28～62岁。治疗前均经胃镜证实为食道静脉曲张破裂出血,并排除心血管疾病因素,治疗过程中有胃管动态观察,不限制抗休克及肝性脑病等一些对症支持治疗。出血停止的判断标准为:胃管中无血性物抽出。暗红色大便消失,血压平稳,呼吸、心率稳定。 2 治疗方法 开始脑垂体后叶素剂量为0.4U/分静滴,6～8h无活动性出血后,脑垂体后叶素减量0.2U/分,再静滴24～48h维持。若0.4U/分静滴12h仍有活动性出血则视为无效,另外考虑其他方法治疗。若减量维持后又出现活动性出血,可再用0.4U/分静滴治疗。
1 clinical data from 1989 to 1997 in our hospital were collected cirrhosis esophageal variceal bleeding in more than 1000ml 45 cases, 38 males and 7 females, aged 28 to 62 years. Gastroscopy before treatment were confirmed as esophageal variceal bleeding and rule out cardiovascular disease factors, the treatment of gastric tube dynamic observation does not limit anti-shock and hepatic encephalopathy and some symptomatic and supportive treatment. Bleeding to stop the judgment criteria: no obstruction in the stomach out. Dark red stool disappeared, blood pressure steady, breathing, stable heart rate. 2 treatment pituitrin dose beginning 0.4U / min intravenous infusion, 6 ~ 8h no active bleeding, pituitrin reduction 0.2U / min, then intravenous infusion of 24 ~ 48h maintained. If 0.4U / min intravenous infusion of 12h still active bleeding is considered invalid, in addition to consider other methods of treatment. If the loss of maintenance and then there active bleeding, you can reuse 0.4U / min intravenous therapy.