自从 196 5年ｃｈｅｓｔｍａｎ和Ｓｍｉｔｈ首先开始软骨细胞体外培养用于软骨缺损修复的研究以来[1] ,人们开始对关节软骨损伤不能通过自身的软骨增殖修复的概念有了新的认识。实验证明不仅年幼且年老的关节软骨标本仍可在体外培养出新生透明软骨[2 ] 。虽然软骨细胞增殖能力 Since chestman and Smith first started the study of chondrocytes cultured in vitro for repair of cartilage defects in 1956, [1] a new understanding of the concept that articular cartilage damage can not be repaired by its own cartilage proliferation has been initiated. Experiments show that not only young and old articular cartilage specimens can still be cultured in vitro hyaline cartilage [2]. Although chondrocytes proliferate