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RTX是一种从大戟色素体 (类似仙人掌 )的树脂中提炼出来的刺激性干乳胶 ,可与特异性受体 (vanilloid受体亚型 1,VR1)结合。低浓度 ( 1nM至 10mM)的RTX即可导致大量钙离子流入C纤维神经元细胞并使之脱敏 ;可使神经生长因子灭活 ;可减少P物质、降钙素基因相关肽和其他神经蛋白的合成 ;可作用于含速激肽 (为疼痛介质 )的神经纤维。通过膀胱灌注RTX可减少或抑制逼尿肌自主活动 ,减弱神经纤维对有害刺激的识别能力 ,改善膀胱顺应性 ,达到治疗逼尿肌高反射、低顺应性膀胱、逼尿肌不稳定、膀胱痛的目的。与辣椒辣素相比 ,RTX疗效更显著、并发症少、病人易于接受 ,不会促进或引发癌症 ,在治疗下尿路症状方面具有广阔前景。
RTX is an irritating dry latex extracted from a resin of Euphorbiaceae (cactus-like) that binds to a specific receptor (vanilloid receptor subtype 1, VR1). Low concentration (1nM to 10mM) of RTX can lead to a large number of calcium ions into C fiber neurons and desensitization; nerve growth factor inactivation; can reduce substance P, calcitonin gene-related peptide and other neuroproteins ; Can act on tachykinins (pain media) of nerve fibers. Intravesical instillation of RTX can reduce or inhibit detrusor autonomic activity, diminish the ability of nerve fiber to recognize harmful stimuli, improve bladder compliance, and achieve high detrusor reflexes, low compliance bladder, detrusor instability, bladder pain the goal of. Compared with capsaicin, RTX is more effective and has fewer complications. Patients are easy to accept, do not promote or trigger cancer, and have broad prospects for treating lower urinary tract symptoms.