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目的探讨无水酒精门静脉栓塞(PVE)对肝硬化的影响。方法正常和肝硬化SD大鼠门脉(PV)内注射无水酒精,观测肝脏解剖、病理、生化以及PV血流动力学的变化。结果 0.05ml/100g注射剂量下正常大鼠存活率100%,肝硬化大鼠仅40.9%。后者接受0.03%ml/100g无水酒精PVE后,非栓塞肝叶肥大显著,肝实质损害轻到中度,肝功能、PV压和血流量变化轻微短暂。结论肝硬化时无水酒精PVE只要剂量适当是安全的,针对栓塞对肝脏的影响可采取相应的保护措施。
Objective To investigate the effect of anhydrous alcoholic portal vein embolization (PVE) on cirrhosis. Methods Normal and cirrhotic SD rats were injected with anhydrous alcohol into the portal vein to observe the changes of liver anatomy, pathology, biochemistry and PV hemodynamics. Results The survival rate of normal rats was 100% at the dose of 0.05ml / 100g and only 40.9% of the rats with cirrhosis. The latter received 0.03% ml / 100g of anhydrous alcohol PVE, non-occluded livers significantly hypertrophy, mild to moderate hepatic impairment, changes in liver function, PV pressure and blood flow slightly transient. Conclusions As long as the dose of ethanol-free PVE in cirrhosis is appropriate, it is safe to take protective measures against the effects of embolism on the liver.