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目的 了解子宫颈上皮内瘤样病变 (CIN)及鳞癌 (SCC)中p5 3与MDM2表达及相关性。方法 用免疫组化SP法检测MDM2及p5 3蛋白在正常宫颈上皮、CIN、SCC中的表达 ,共 76例。结果 ①随着宫颈病变加重 ,MDM2、p5 3表达率均渐增高 ,二者在正常宫颈、CIN、SCC的表达率分别为 :MDM2的表达为 0、13 64 %、44 12 % ;p5 3的表达为 5 0 0 %、18 18%、47 0 6%。MDM2、p5 3在浸润癌组较CIN及正常宫颈组明显增高。②MDM2的表达与p5 3的聚积在统计学上未显示出有相关性。结论 MDM2、p5 3可能参与宫颈癌的发生、发展 ,对宫颈癌的诊断和治疗具有一定意义。
Objective To investigate the expressions of p5 3 and MDM2 in cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma (SCC) and their correlation. Methods Immunohistochemical SP method was used to detect the expression of MDM2 and p53 in normal cervical epithelium, CIN and SCC, a total of 76 cases. Results ① The expression rates of MDM2 and p5 3 were gradually increased with the increase of cervical lesions. The expression rates of MDM2 and p5 3 in normal cervix, CIN and SCC were 0,134% and 44 12%, respectively. Expressed as 500%, 18 18%, 47 0%. MDM2, p5 3 in invasive cancer group than CIN and normal cervical group was significantly higher. ②MDM2 expression and p5 3 accumulation in the statistical did not show any correlation. Conclusions MDM2, p5 3 may participate in the occurrence and development of cervical cancer and have certain significance for the diagnosis and treatment of cervical cancer.