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目的：探讨放射状角膜切开（ＲＫ）术后角膜内皮细胞（ＣＥＣ）形态计量学变化及其临床意义。方法：对１６例患者（２８眼）在ＲＫ术前、术后２周至１年期间进行了活体ＣＥＣ显微镜观察和计算机图像分析。结果：与术前相比，术后早期细胞面积变异系数、长径、周长明显扩大，形状系数减小（Ｐ＜０．０１），术后６个月，上述各形态计量学指标基本恢复正常（Ｐ＞０．０５）；在术后１年内细胞密度虽有下降，但无统计学意义。结论：ＲＫ导致的ＣＥＣ损伤可修复，但修复需要一定条件。为预防ＣＥＣ功能失代偿等各种并发症，围手术期应高度重视角膜内皮的保护。
Objective: To investigate the morphometric changes of corneal endothelial cells (CEC) after radial keratotomy (RK) and its clinical significance. METHODS: Sixteen patients (28 eyes) underwent CEC microscopy and computer image analysis before RK and 2 weeks to 1 year after surgery. Results: Compared with the preoperative, the coefficient of variation of cell area at the early postoperative phase, the major axis and the circumference of the tumor were significantly enlarged and the shape coefficient was decreased (P <0.01). At 6 months after operation, the above morphometric parameters recovered Normal (P> 0.05). Although the cell density decreased within 1 year after operation, it was not statistically significant. Conclusion: The RK-induced CEC injury can be repaired, but the repair needs certain conditions. In order to prevent CEC decompensation and other complications, perioperative period should attach great importance to the protection of the corneal endothelium.