目的：研究肿瘤浸润淋巴细胞（ＴＩＬ）与ＩＬ２联合体内诱导凋亡产生抗瘤作用机理，为应用ＴＩＬ治疗肺癌提供依据。方法：从Ｌｅｗｉｓ肺癌（ＬＬＣ）瘤体中分离提取ＴＩＬ，在含１０００Ｕ／ｍｌＩＬ２的完全培养基中培养后，与ＬＬＣ细胞以１０∶１接种于Ｃ５７ＢＬ／６小鼠腋下，每日１０００Ｕ／ｍｌＩＬ２瘤内注射，并测量肿瘤体积，于接种后第１８天处死小鼠。结果：发现ＴＩＬ加ＩＬ２有明显地抑制ＬＬＣ生长的作用（Ｐ＜０００１），ＨＥ染色、ＴＵＮＥＬ和电镜均证实ＴＩＬ加ＩＬ２可明显诱导Ｌｅｗｉｓ肺癌细胞凋亡。结论：诱导凋亡产生可能是ＴＩＬ与ＩＬ２联合抗瘤的机制之一 Objective: To study tumor-infiltrating lymphocytes (TIL) and IL  2 in vivo apoptosis induced by anti-tumor mechanism of action for the treatment of lung cancer with TIL provide the basis. Methods: TIL was isolated and extracted from Lewis lung carcinoma (LLC) tumor. After cultured in complete medium containing 1000 U / ml IL-2, LLC cells were inoculated into the axilla of C57BL / 6 mice at 10: / MlIL 2 intratumoral injection, and measure the tumor volume, the mice were sacrificed 18 days after inoculation. Results: It was found that TIL plus IL 2 significantly inhibited the growth of LLC (P <0001), HE staining, TUNEL and electron microscopy were confirmed TIL plus IL 2 can significantly induce Lewis lung cancer cell apoptosis. Conclusion: The induction of apoptosis may be TIL and IL  2 joint anti-tumor mechanism