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骨质疏松(osteoporosis,OP)是一种以骨量减少,骨的微细结构破坏为特征的全身代谢性骨骼疾病。瘦素(Leptin,Lep)是由脂肪细胞分泌的一种肽类激素,对骨量正面和负面都有影响,并对骨代谢发挥调节作用。在体外,Lep可调节成骨细胞的增殖,抑制成骨细胞依赖的破骨细胞的重吸收;在体内主要是负面作用,Lep抑制脑干中5-羟色胺(5-hydroxy tryptamine,5-ht)的合成,增加交感神经信号由下丘脑到骨的输出。但临床试验中关于Lep与老年性OP之间的相关性和Lep在中枢神经系统、外周组织中的作用及存在的问题尚未明确,文中就Lep与老年性OP的相关性最新研究进展作一综述。
Osteoporosis (OP) is a systemic metabolic bone disorder characterized by decreased bone mass and destruction of the fine structure of the bone. Leptin (Lep), a peptide hormone secreted by fat cells, has positive and negative effects on bone mass and plays a regulatory role in bone metabolism. In vitro, Lep regulates the proliferation of osteoblasts and inhibits osteoclast-dependent osteoclast reabsorption. In vivo, Lep inhibits the 5-hydroxytryptamine (5-ht) The synthesis increases the output of sympathetic signals from the hypothalamus to the bone. However, the correlation between Lep and senile OP and the role and existing problems of Lep in the central nervous system and peripheral tissues have not been clarified in clinical trials. In this review, we review the latest research progress on the relationship between Lep and senile OP .