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目的 揭示妊娠早期对妇女碘营养和垂体 -甲状腺功能的影响。方法 一次性收集连续居住在深圳市 3年以上 ,经济收入中等 ,受孕第 12～ 14周妇女尿及全血 ,采用砷铈催化分光光度法测定尿碘和血清碘 ,化学发光法测定垂体 -甲状腺激素。结果 110例早孕组尿碘 14 6 5 μg/L及血清碘 (82 2 μg/L)明显低于 110例未孕组 (2 93μg/L和90 8μg/L ,P均 <0 0 1) ;其中 70例早孕组FT4(15 2 5 pmol/L)低于未孕组 (16 75 pmol/L ,P <0 0 1) ;FrT3 /FT4(0 331)和TSHs(2 4 1mU/L)明显高于未孕组 (0 314和 1 84mU/ ,P均 <0 0 1)。而早孕组尿碘 <10 0 μg/L有 14 5 %高于未孕组 5 2 % (P <0 0 5 )。结论 在碘营养充足地区早孕第 12～ 14周妇女碘营养和垂体 -甲状腺功能可发生变化。体内碘储备已开始下降 ,FT4降低 ,而TSHs开始增高 ,其中有 3例 (4 3% )超过临床参考值 ,孕期防治IDD应从孕前开始
Objective To reveal the effects of early pregnancy on iodine nutrition and pituitary-thyroid function in women. Methods The urinary and whole blood of women who lived in Shenzhen for more than 3 years with moderate economic income and were in the twelfth to fourteenth weeks of pregnancy were collected. Urinary iodine and serum iodine were determined by arsenic and cerium catalytic spectrophotometry. The levels of pituitary - thyroid hormone. Results The urinary iodine 14 6 5 μg / L and serum iodine 82 (110 μg / L) in 110 cases of early pregnancy were significantly lower than those in 110 cases without pregnancy (2 93 μg / L and 90 8 μg / L, P all <0.01). FT4 (15 2 5 pmol / L) was lower in 70 early pregnancy groups than in non-pregnant group (16 75 pmol / L, P <0.01); FrT3 / FT4 (0 331) and TSHs Higher than the non-pregnant group (0 314 and 1 84mU /, P <0 01). However, the urinary iodine <10 0 μg / L in early pregnancy group was 14 5% higher than that in non-pregnant group (P <0.05). Conclusion Iodine nutrition and pituitary - thyroid function may change in the twelfth to fourteenth weeks of early pregnancy in iodine - rich areas. Iodine reserve has begun to decline in vivo, FT4 decreased, and TSHs began to increase, of which 3 cases (43%) exceeded the clinical reference value, prevention and treatment of IDD during pregnancy should be started