论文部分内容阅读
以邻、间、对氨基苯甲酸为起始原料,在盐酸存在下分别与双氰胺合成了中间体邻、间、对双胍基苯甲酸盐酸盐,分别研究了邻、间、对双胍基苯甲酸盐酸盐对革兰氏菌的抗菌活性。实验表明,邻、间、对双胍基苯甲酸盐酸盐对大肠杆菌、金黄色葡萄球菌都具有抑制作用,抗菌活性随浓度的增加而增强;邻双胍基苯甲酸盐酸盐对大肠杆菌、金黄色葡萄球菌最低抑菌浓度分别为0.064mg.mL-1和0.032mg.mL-1,优于间、对双胍基苯甲酸盐酸盐。
The o-, m- and p-guanidinium benzoate were synthesized from o-, m- and p-aminobenzoic acid respectively with dicyandiamide in the presence of hydrochloric acid. The effects of o-, m-, and p-guanidine Antibacterial Activity of Benzyl Hydrochloride to Gram. Experiments show that o-, m-, p-guanidinium benzoate hydrochloride has inhibitory effect on Escherichia coli and Staphylococcus aureus, and the antibacterial activity increases with the increase of the concentration; the o-biguanidin benzoate hydrochloride exerts an inhibitory effect on Escherichia coli , The minimum inhibitory concentration of Staphylococcus aureus were 0.064mg.mL-1 and 0.032mg.mL-1, respectively, better than that of guanidinium benzoate hydrochloride.