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目的:研究奥美拉唑在汉族健康人体的药动学。方法:选择10名健康受试者,男女各半,单剂量口服奥美拉唑肠溶片40mg后,于不同时间点采静脉血,经血浆样品处理后用高效液相色谱法测定人血浆中奥美拉唑的浓度。用DAS2.0药动学软件进行数据处理,SPSS11.5软件进行统计分析。结果:主要药动学参数Cm ax为(760.49±581.232)μg.L-1,tm ax为(2.7±0.823)h,t1/2为(1.601±1.282)h,AUC0~12为(1437.61±798.045)μg.h.L-1,AUC0~∞为(1470.09±769.475)μg.h.L-1。主要药动学参数与文献报道基本一致,且性别间主要药动学参数差异无统计学意义。结论:本方法可用于奥美拉唑的药动学研究。
Objective: To study the pharmacokinetics of omeprazole in healthy Han people. Methods: Ten healthy volunteers were enrolled in this study. One male and half female were enrolled in this study. Omeprazole enteric-coated tablets (40 mg) were taken orally and venous blood was collected at different time points. After plasma samples were processed, Omeprazole concentration. DAS2.0 pharmacokinetic software for data processing, SPSS11.5 software for statistical analysis. RESULTS: The major pharmacokinetic parameters Cm ax was (760.49 ± 581.232) μg.L-1, tm ax was (2.7 ± 0.823) h, t1 / 2 was (1.601 ± 1.282) h and AUC0-12 was (1437.61 ± 798.045 ) μg.hL-1, AUC0 ~ ∞ was (1470.09 ± 769.475) μg.hL-1. The main pharmacokinetic parameters were basically consistent with those reported in the literature, and there was no significant difference in the main pharmacokinetic parameters between the sexes. Conclusion: This method can be used to study the pharmacokinetics of omeprazole.