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目的:研究桂枝茯苓丸对前列腺增生模型小鼠的影响。方法:ip丙酸睾酮素复制小鼠良性前列腺增生模型。给药组分别ig给予桂枝茯苓丸高、中、低剂量;并用前列康作阳性对照。于末次给药24h后处死动物,取前列腺称量其湿质量,并进行病理学检查。结果:桂枝茯苓丸给药组小鼠前列腺指数均显著低于模型组(P<0.01);病理镜检显示桂枝茯苓丸给药组前列腺减轻,同时可见坏死灶的形成和大量的腺体上皮细胞脱落到腺腔内或凋亡,尤以高、中剂量组最为显著。结论:桂枝茯苓丸可显著抑制小鼠前列腺增生。
Objective: To study the effects of Guizhi Fuling capsule on prostatic hyperplasia model mice. Method: ip testosterone propionate replicate model of benign prostatic hyperplasia in mice. The treatment group were given Guizhi Fuling pill igh high, medium and low doses; and Qianlie Kang positive control. Animals were sacrificed 24h after the last administration, the wet weight of the prostate was weighed and pathological examination was performed. Results: The prostatic index in Guizhi Fuling Capsule administration group was significantly lower than that in model group (P <0.01). Pathological examination showed that the prostatic gland was relieved in Guizhi Fuling Capsule administration group and the formation of necrotic lesions and a large number of glands Epithelial cells shed into the glandular cavity or apoptosis, especially in high and medium dose groups the most significant. Conclusion: Guizhi Fuling pill can significantly inhibit the prostatic hyperplasia in mice.