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本文报告Temocillin对490株致病菌体外抗菌活性的研究,并与其它6种β-内酰胺类抗生素和庆大霉素进行了比较。结果显示,本品对大多数肠道杆菌有较好抗菌活性,MIC_(50)为1～4μg/ml。MIC_(90)均为≤16μg/ml。本品对沙雷氏菌中度敏感,其MIC_(90)为3μg/ml;对绿脓杆菌和不动杆菌耐药。革蓝氏阳性球菌对本品不敏感。同其它几种抗生素比较,本品对大多数肠道杆菌的抗菌活性较头孢噻肟略差,与Moxalactam接近,较哌拉西林、头孢唑啉、头孢西丁、头孢呋肟和庆大霉素为强。本研究为该药的临床应用提供参考。
This article reports the in vitro antibacterial activity of Temocillin against 490 pathogenic bacteria and compares it with six other β-lactam antibiotics and gentamicin. The results showed that the product has good antibacterial activity against most enterobacteria, and the MIC 50 is 1 to 4 μg / ml. MIC_ (90) were all ≤16μg / ml. This product is moderately sensitive to Serratia, its MIC_ (90) is 3μg / ml; resistant to Pseudomonas aeruginosa and Acinetobacter. Gram-positive cocci insensitive to this product. Compared with other antibiotics, the antibacterial activity of this product to most enterobacteriaceae is slightly worse than that of cefotaxime, close to that of Moxalactam. Compared with piperacillin, cefazolin, cefoxitin, cefuroxime and gentamycin Strong. This study provides a reference for the clinical application of this medicine.