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目的:探讨用萘必洛尔(nebivolol)替代β-抑制剂治疗原发性高血压病人勃起功能的效果。方法:44名中青年原发性高血压男性病人(31-65岁)来我院门诊部就诊,接受β-抑制剂(阿替洛尔、美托洛尔或比索洛尔)治疗6个月以上。所有病人填写勃起功能国际指数问卷(International Index for Erectile Function)后转用等量萘必洛尔治疗3个月,治疗结束后再次填写相同问卷。结果:这44名接受β-抑制剂(阿替洛尔、美托洛尔或比索洛尔)治疗的病人的心脏收缩压和舒张压都未随治疗变化而改变,其中有29人(65.9%)出现勃起功能障碍(ED)。经3个月萘必洛尔治疗后,这29名病人中有20人(69%)勃起功能指标得到明显改善,其中11人恢复正常。结论:萘必洛尔可能对治疗 ED 具有良好效果(可能是通过提高一氧化氮的有效性实现的),但仍需要进一步的前瞻性安慰剂对照研究来证实。
Objective: To explore the effect of nebivolol instead of β-inhibitor on erectile function in patients with essential hypertension. Methods: Forty-four young and middle-aged patients with essential hypertension (31-65 years old) were referred to our outpatient department and were treated with β-inhibitors (atenolol, metoprolol or bisoprolol) for 6 months the above. All patients were enrolled in the International Index for Erectile Function and switched to equivalent naphthalene mellofiban for 3 months. The same questionnaire was filled in again after treatment. Results: The systolic and diastolic pressures of the 44 patients treated with β-inhibitors (atenolol, metoprolol or bisoprolol) did not change with treatment, with 29 (65.9% ) Had erectile dysfunction (ED). After 3 months of treatment with nebivolol, eighteen (69%) of these 29 patients achieved marked improvement in their erectile function and 11 returned to normal. CONCLUSIONS: Nalbirol may have a good effect on the treatment of ED, possibly by increasing the availability of nitric oxide, but further prospective, placebo-controlled studies are needed to confirm this.