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目的：探讨孟鲁司特预防和治疗创伤后膝关节僵硬的临床疗效。方法选取福建省福州市第二医院2015年4—7月收治的创伤后单膝关节僵硬患者50例。按照就诊顺序分为治疗组与对照组，各25例。患者均进行膝关节康复运动训练和干扰电治疗，治疗组患者在此基础上给予口服孟鲁司特钠片治疗。比较两组患者治疗前、治疗后第2、3、4周关节僵硬指标〔由改良数字评分法（VAS）评估〕、关节活动指标及不良反应发生情况。结果治疗前两组患者 VAS 评分和关节活动指标比较，差异无统计学意义（P ﹥0.05）；治疗后第2、3、4周治疗组患者 VAS 评分低于对照组，关节活动指标高于对照组，差异有统计学意义（ P ﹤0.05）。患者治疗后均未出现关节感染、关节血肿、下肢深静脉血栓等严重并发症。治疗组患者中发生不良反应1例，停药后症状缓解。结论孟鲁司特预防和治疗创伤后膝关节僵硬的临床疗效确切，可有效改善患者关节僵硬程度，提高活动范围，且安全性高。“,”Objective To investigate the prevention and treatment effect of montelukast in treating knee joint stiffness after trauma. Methods A total of 50 patients with single knee joint stiffness after trauma were selected from April to July 2015 in the Second Hospital of Fuzhou City,which were divided into treatment group and control group by registration order,25 cases in each group. All patients underwent knee joint rehabilitation training and treatment of electrical interference,the patients in the treatment group were given oral montelukast sodium tablets treatment. Before treatment,treatment after 2,3,4 weeks joint stiffness index〔(Visual Analogue Scale)VAS〕,the joint activity index,the occurrence of adverse reactions of the two groups were compared. Results Before treatment VAS score and joint activity index between the two groups showed no significant differences(P ﹥ 0. 05);after treatment 2,3,4 weeks VAS score of treatment group were lower than control group,the joint activity index was higher than the control group(P ﹤ 0. 05). All the patients after treatment,there were no joint hematoma, infection,deep vein thrombosis and other serious complications. Patients in the treatment group had 1 case of adverse reactions, stop drug relief of symptoms. Conclusion The prevention and treatment effect of montelukast in treating knee joint stiffness af-ter trauma is exact,which can effectively improve the degree of joint stiffness,improve the range of activities,and has high safety.