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间质性肺疾病(IPD)患者睡眠中常有 SaO_2下降,本文观察14例 IPD 患者睡眠中 SaO_2变化与清醒期对高 CO_2通气反应(HCVR)和低氧通气反应(HVR)的关系。14例 IPD 中12例为间质性肺炎,2例伴类风湿性关节炎,病情均处于稳定状态.于日间清醒状态下测定肺功能、动脉血气等.夜间睡眠中测脑电、眼电和颌下肌电图等,用耳血氧计测 SaO_2,入睡前连续15分钟的平均值为基础 SaO_2,此后每30秒测1次 NREM(非快速眼动)及 REM(快速眼动)睡眠期 SaO_2变化。同时记录睡眠中每小时呼吸暂停及呼吸低下的次数和1夜中低氧性唤醒反应的次数。结果 14例均有限制性通气功能障碍,VC<正常预计值的80%(平均57±12%),无1例阻塞性通气功能碍障者,FEV_1/FVC%均>70%(平均81±8%)。平均 PaO_2 73±9mmHg,PaCO_2 42±4mmHg,基础 SaO_2±3%。10例低氧血症发作>4%,其中5例>10%,15 3次 SaO_2减低中141次>4%,24次>
In patients with interstitial lung disease (IPD), SaO 2 is often decreased during sleep. In this paper, the relationship between SaO 2 changes during sleep and the effects of high carbon dioxide ventilation (HCVR) and hypoxic ventilatory response (HVR) in 14 IPD patients was observed. Among the 14 cases of IPD, 12 cases were interstitial pneumonia and 2 cases were accompanied by rheumatoid arthritis, the condition was in a steady state.Determination of lung function, arterial blood gas and so on in the daytime awake state.Electrical Nocturnal EEG And submandibular electromyogram, etc. SaO2 was measured by auricular oximetry and SaO2 was taken as an average of 15 minutes before falling asleep, and then NREM (non-REM) and REM (REM sleep) were measured every 30 seconds Period SaO_2 changes. The number of apnea and hypopneas per hour during sleep and the number of hypoxic arousal reactions in one night were also recorded. Results All 14 patients had restrictive ventilatory dysfunction with VC <80% (mean 57 ± 12%) of the expected normal value, none of the patients with obstructive ventilatory dysfunction and> 70% of FEV 1 / FVC (mean 81 ± 8%). Average PaO 2 73 ± 9mmHg, PaCO 2 42 ± 4mmHg, basal SaO 2 ± 3%. 10 cases of hypoxemia episodes> 4%, of which 5 cases> 10%, 153 times SaO 2 reduction 141 times> 4%, 24 times>