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采用种子乳液聚合法在Fe3O4纳米粒子表面聚合包覆N-异丙基丙烯酰胺(NIPAM)与α-甲基丙烯酸(MAA)的共聚物,制备了磁性热敏聚合物微球Fe3O4/P(NIPAM-co-MAA).利用广角X射线衍射仪(WAXD)、透射电子显微镜(TEM)、zeta粒度仪(DLS)、热重分析(TGA)、振动样品磁力计(VSM)及比表面积测试仪(BET)等对微球的结构与形貌进行了表征,通过紫外-可见光分光光度法(UV-Vis)研究了微球对水溶性模型药物罗丹明B(RhB)的负载和磁感应控制释放行为.结果表明,微球粒径为80～200 nm,比表面积约为30.04m2/g,平均孔径约为24.50 nm;微球中聚合物含量约为73 wt%,磁粒子含量约为20 wt%,饱和磁感应强度为16.49 emu/g,其体积相转变温度(VPTT)约为37.5℃.RhB在微球中的装载量可以达到16.38 mg/g;在外加交变磁场作用下,RhB在模拟肠液和胃液中的磁感应释放量分别达到10.47和13.02 mg/g.
A magnetic thermosensitive polymer microspheres Fe3O4 / P (NIPAM) was prepared by the seed emulsion polymerization on the surface of Fe3O4 nanoparticles, which was coated with NIPAM and α-methacrylic acid (MAA) ray diffraction (WAXD), transmission electron microscopy (TEM), zeta particle size analyzer (DLS), thermogravimetry (TGA), vibrating sample magnetometer (VSM) and specific surface area analyzer BET) were used to characterize the structure and morphology of the microspheres. The UV-Vis spectroscopy was used to study the microspheres’ loading and magnetic induction-controlled release of water-soluble drug Rhodamine B (RhB). The results show that the microspheres have a particle size of 80-200 nm, a specific surface area of about 30.04 m 2 / g and an average pore diameter of about 24.50 nm. The content of the polymer in the microspheres is about 73 wt% and the content of the magnetic particles is about 20 wt% The saturation magnetic flux density was 16.49 emu / g, and the volume phase transition temperature (VPTT) was about 37.5 ℃. RhB loaded in microspheres could reach 16.38 mg / g. Under the action of alternating magnetic field, Magnetic induction in gastric juice reached 10.47 and 13.02 mg / g, respectively.