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动脉粥样硬化是一种免疫相关的大中动脉的慢性炎症性疾病。固有免疫应答和适应性免疫应答均参与动脉粥样硬化的发生,树突状细胞(DC)是联系固有性免疫和适应性免疫的桥梁,在启动机体免疫应答和维持免疫耐受中处于中心地位。本文综述了动脉壁中的DC亚群组成以及DC亚群在动脉粥样硬化炎症免疫中的作用,包括摄取脂质、释放细胞因子和通过调控T细胞从而影响动脉粥样硬化的发生发展,并总结了基于DC疫苗在防治动脉粥样硬化中的研究现状和展望。
Atherosclerosis is a chronic, inflammatory disease of the immune-related middle and large arteries. Both innate immune responses and adaptive immune responses are involved in the development of atherosclerosis. Dendritic cells (DCs) are bridges between innate and adaptive immunity and play a central role in initiating the immune response and maintaining immune tolerance . This review summarizes the role of DC subpopulations in the arterial wall and the DC subsets in atherosclerotic inflammation and immunity, including the uptake of lipids, the release of cytokines, and the development of atherosclerosis through the regulation of T cells The research status and prospect of DC vaccine based on prevention and treatment of atherosclerosis are summarized.