论文部分内容阅读
HLA-G是一种非经典的HLA-I类抗原,作为免疫耐受分子之一,它可通过多种机制参与机体免疫耐受的诱导与维持。大量的研究显示,HLA-G除表达于母胎界面外,在病理条件下HLA-G在周边组织也表达,例如病毒性感染、恶性肿瘤、自身免疫病和器官移植等。影响HLA-G表达的因素包括外源的(LPS、IL-10、IFN-γ等)和内源性(基因多态性等)。本文阐述的重点是HLA-G基因多态性与疾病的关联。
HLA-G is a non-classical HLA-I antigen. As one of the immune tolerance molecules, HLA-G can participate in the induction and maintenance of immune tolerance through a variety of mechanisms. A large number of studies have shown that, HLA-G in addition to the expression of the maternal-fetal interface, under the pathological conditions in the expression of HLA-G in peripheral tissues, such as viral infections, malignancies, autoimmune diseases and organ transplantation. Factors affecting HLA-G expression include exogenous (LPS, IL-10, IFN-γ, etc.) and endogenous (gene polymorphisms, etc.). The focus of this article is the association of HLA-G gene polymorphisms with disease.