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目的:观察奥美拉唑联合多潘立酮(吗丁啉)、硫糖铝治疗反流性食管炎(RE)的临床效果。方法:将82例经内镜等检查诊断的RE患者随机分为两组:治疗组42例,应用奥美拉唑20 mg、2次／d,吗丁啉10 mg、3次／d,硫糖铝1.0 g、4次／d治疗;对照组40例,用雷尼替丁150 mg、2次／d,吗丁啉及硫糖铝(用法同治疗组)。两组疗程均为6周。记录症状积分。疗程结束复查内镜。结果:治疗组临床总有效率95.2％,优于对照组的80.O％(P<0.01);治疗组反酸症状的改善优于对照组(P<0.05),其余症状的改善两组比较无统计学意义(P>0.05)。胃镜下食管粘膜病损显效率与总有效率,治疗组为81.0％及97.6％,对照组为55.0％及82.5％。两组比较均有统计学意义(P<0.01)。结论;奥美拉唑与吗丁啉、硫糖铝联合用药是目前治疗RE较为理想的一种有效疗法。
Objective: To observe the clinical effects of omeprazole combined with domperidone and sucralfate in the treatment of reflux esophagitis (RE). Methods: 82 patients with RE diagnosed by endoscopy and other tests were randomly divided into two groups: treatment group (n = 42), omeprazole 20 mg twice daily, domperidone 10 mg 3 times daily, 1.0 g aluminum saccharide, 4 times / d treatment; control group of 40 cases, with ranitidine 150 mg, 2 times / d, domperidone and sucralfate (use the same treatment group). The two courses of treatment were 6 weeks. Record symptom scores. End of treatment review endoscopy. Results: The total clinical effective rate was 95.2% in the treatment group, which was better than 80.0% in the control group (P <0.01). The improvement of the acid reflux symptom in the treatment group was better than that in the control group (P <0.05) No statistical significance (P> 0.05). Gastroscopic esophageal mucosal lesions showed markedly effective and total effective rate of 81.0% and 97.6% in the treatment group and 55.0% and 82.5% in the control group, respectively. The two groups were statistically significant (P <0.01). Conclusion; Combination of omeprazole with domperidone and sucralfate is an effective treatment for RE.