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目的对成都地区2011年1月至2014年8月青年群体高尿酸血症(hyperuricemia,HUA)状况及发展趋势进行回顾性分析。方法 2011年1月至2014年8月成都地区健康体检人群共计为86 779名,分为青年组和中年组、老年组进行分析。青年组年龄为18~39岁,平均年龄(28.49±5.78)岁;中年组年龄40~59岁,平均年龄(48.52±6.74)岁。老年组年龄60~87岁,平均年龄(67.22±5.81)岁。高尿酸血症诊断标准:男性≥420μmol/L,女性≥357μmol/L。采用SPSS 17.0软件对数据进行统计学分析,P<0.05为差异有统计学意义。结果总体人群HUA阳性率为16.29%,4年中呈逐年升高(χ2=133.36,P<0.05);HUA阳性率比较:男性青年组大于中年组、老年组(χ2=107.31,P<0.05);女性青年组小于女性中年组、老年组(χ2=591.93,P<0.05);男、女性青年组各自的HUA阳性率呈逐年上升趋势(男r=0.988,P<0.05;女r=0.985,P<0.05)。尿酸水平的比较:男性青年组与中年组比较(t=0.288,P>0.05)、与老年组比较(t=0.180,P>0.05)尿酸水平均差异无统计学意义;女性青年组与中年组比较(t=-0.303,P>0.05)、与老年组比较(t=-0.535,P>0.05)尿酸水平差异无统计学意义;青年组HUA尿酸水平连续4年无差异性改变(男:t=0.003,P>0.05;女:t=0.005,P>0.05)。结论本研究HUA年青化趋势明显,男性青年群体无论HUA阳性率及尿酸水平均大于或等于整体人群;男、女青年组的HUA阳性率与尿酸水平的逐年递增应引起高度关注。为提高全民身体素质,对于HUA年青化的状态及其进展,还需长期关注和研究。
Objective To retrospectively analyze the status and development trend of hyperuricemia (HUA) in young people in Chengdu from January 2011 to August 2014. Methods From January 2011 to August 2014, the health examination population in Chengdu totaled 86,779 and was divided into young group, middle age group and elder group for analysis. The age of the youth group was 18-39 years old, with an average age of (28.49 ± 5.78) years. The middle age group was 40-59 years old and the mean age was (48.52 ± 6.74) years old. The elderly group aged 60 to 87 years, mean age (67.22 ± 5.81) years old. Hyperuricemia diagnostic criteria: male ≥ 420μmol / L, female ≥ 357μmol / L. Data were analyzed by SPSS 17.0 software, P <0.05 was considered statistically significant. Results The prevalence of HUA in the general population was 16.29%, increased year by year (χ2 = 133.36, P <0.05). The positive rate of HUA was higher in male youth than in middle age and old age group (χ2 = 107.31, P <0.05) ). The positive rates of HUA in young women were lower than those in middle-aged women and old people (χ2 = 591.93, P <0.05). The positive rates of HUA in young women and men were increased year by year (r = 0.988, 0.985, P <0.05). Compared with the elderly group (t = 0.180, P> 0.05), there was no significant difference in uric acid levels between the young men and the middle-aged group (t = 0.288, P> 0.05) There was no significant difference in uric acid levels between the two groups (t = -0.303, P> 0.05). There was no significant difference in uric acid levels between the young group and the elderly group (t = -0.535, P> 0.05) : t = 0.003, P> 0.05; female: t = 0.005, P> 0.05). Conclusions The trend of HUA youthfulness is obvious in this study. The positive rate of HUA and the level of uric acid in the male youth population are both greater than or equal to the overall population. The HUA positive rate and the increasing uric acid level in the male and female youth groups are of great concern. In order to improve the physical fitness of the general public, we need long-term attention and research on the status of HUA youth and its progress.