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目的观察自拟中药解郁方在治疗更年期综合征中的临床效果。方法选择2014年3月—2015年4月收治的106例更年期综合征患者作为研究对象,随机分为对照组和治疗组各53例。对照组采用艾司西酞普兰治疗,治疗组在对照组的基础上联合自拟解郁方治疗,两组均治疗8周。采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评价两组疗效,以不良反应、实验室检查及心电图检查评价该疗法的安全性。计量资料组间比较采用t检验,组内比较采用配对t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗后,治疗组总有效率为90.57%,显著高于对照组的75.47%,差异有统计学意义(P<0.05)。治疗后2、4、8周治疗组与对照组HAMD评分分别为(16.56±3.98)、(13.81±3.79)、(8.76±3.45)、(19.43±4.12)、(15.55±3.98)、(10.27±2.38)分,均低于治疗前的(28.12±2.33)、(27.93±3.62)分,差异均有统计学意义(均P<0.05)。两组治疗后各时间点HAMD评分比较差异均有统计学意义(均P<0.05)。治疗组不良反应发生率为11.32%,低于对照组的35.85%,差异有统计学意义(P<0.05)。结论自拟解郁方联合艾司西酞普兰治疗更年期综合征能显著提高患者社会适应能力,改善临床症状,值得推广应用。
Objective To observe the clinical efficacy of self-made traditional Chinese medicine Jieyu Decoction in the treatment of menopausal syndrome. Methods From March 2014 to April 2015, 106 cases of climacteric syndrome patients were selected as study subjects and randomly divided into control group and treatment group of 53 cases each. The control group was treated with escitalopram. The treatment group was treated with Jieyu Decoction on the basis of the control group, and both groups were treated for 8 weeks. The Hamilton depression scale (HAMD) was used to evaluate the efficacy of the two groups. Adverse reactions, laboratory tests and electrocardiogram were used to evaluate the safety of the therapy. Measurement data were compared between groups using t test, the group was compared using paired t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results After treatment, the total effective rate of the treatment group was 90.57%, which was significantly higher than that of the control group (75.47%), the difference was statistically significant (P <0.05). The HAMD scores of the treatment group and the control group were (16.56 ± 3.98), (13.81 ± 3.79), (8.76 ± 3.45), (19.43 ± 4.12), (15.55 ± 3.98) and (10.27 ± 2.38), respectively, which were lower than those before treatment (28.12 ± 2.33) and (27.93 ± 3.62), respectively. The differences were statistically significant (all P <0.05). There was significant difference in HAMD score between two groups after treatment (all P <0.05). The incidence of adverse reactions in the treatment group was 11.32%, which was lower than that in the control group (35.85%), the difference was statistically significant (P <0.05). Conclusion Self-made Jieyu Decoction combined with escitalopram in the treatment of menopausal syndrome can significantly improve the social adaptability of patients and improve clinical symptoms, it is worth promoting the application.