细胞信号转导即细胞信息代谢,已成为目前普遍关注和发展迅速的细胞生物学问题,通过信号分子所携信息在细胞内传递,对细胞代谢、生长、增殖、凋亡、伸展、迁移及癌变等进行全方位、多层次调控[1]。信号分子p130Cas(p130 Crk-associated substance)是细胞内普遍存在的、与v-Crk和 Cell signal transduction is the metabolism of cell information, which has become the current widespread concern and rapid development of cell biology. The information carried by signal molecules is transmitted in the cell, which has important effects on cell metabolism, growth, proliferation, apoptosis, extension, migration and carcinogenesis Such as all-round, multi-level regulation [1]. The signal molecule p130Cas (p130 Crk-associated substance) is ubiquitously intracellular, with v-Crk and