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目的了解Galectin-3和CD44v6在甲状腺良恶性结节中的表达差异,探讨两项指标在鉴别甲状腺结节良恶性方面的临床应用价值。方法采用免疫组化ABC法,检测143例甲状腺良恶性结节的石蜡标本中Galectin-3蛋白及CD44v6蛋白的表达差异。结果Galectin-3和CD44v6在甲状腺癌中的阳性率显著高于良性结节及正常组织中的阳性率(P<0.01)。Galectin-3联合CD44v6检测在鉴别甲状腺结节良恶性方面的敏感性、特异性和诊断准确率分别为80.8%、93.4%和88.8%,而单独检测Galectin-3时,敏感性、特异性和诊断准确率分别为96.2%、90.1%和92.3%。结论Galectin-3和CD44v6(尤其是前者)的免疫组化检测有助于甲状腺癌的鉴别诊断。
Objective To investigate the expression of Galectin-3 and CD44v6 in benign and malignant thyroid nodules, and to explore the clinical value of the two indexes in differentiating benign and malignant thyroid nodules. Methods Immunohistochemical ABC method was used to detect the expression of Galectin-3 protein and CD44v6 protein in 143 cases of benign and malignant thyroid nodules. Results The positive rates of Galectin-3 and CD44v6 in thyroid cancer were significantly higher than those in benign nodules and normal tissues (P <0.01). The sensitivity, specificity and diagnostic accuracy of Galectin-3 combined with CD44v6 in differentiating benign and malignant thyroid nodules were 80.8%, 93.4% and 88.8%, respectively. The sensitivity, specificity and diagnosis of Galectin-3 alone The accuracy rate was 96.2%, 90.1% and 92.3% respectively. Conclusion Immunohistochemical detection of Galectin-3 and CD44v6, especially the former, is helpful for the differential diagnosis of thyroid cancer.